DURECT Corporation Presenting at the Jefferies Healthcare Conference

CUPERTINO, Calif., June 21 /PRNewswire-FirstCall/ -- DURECT Corporation announced today that it will present at the Jefferies Healthcare Conference being held in New York City. Matthew J. Hogan, Chief Financial Officer, will be presenting at the conference on June 27, 2007 at 9:10 AM Eastern Time.

(Logo: http://www.newscom.com/cgi-bin/prnh/20020717/DRRXLOGO)

A live audio webcast of the presentation will be available by accessing DURECT’s homepage at http://www.durect.com and clicking “Investor Relations”. If you are unable to participate during the live webcast, the call will be archived on DURECT’s website under Audio Archive in the “Investor Relations” section.

Webcast Link: http://www.wsw.com/webcast/jeff18/drrx

About DURECT Corporation

DURECT Corporation is an emerging specialty pharmaceutical company developing pharmaceutical systems based on its proprietary drug delivery platform technologies. The Company currently has a number of late-stage pharmaceutical products in development addressing large markets in pain management, with a number of research programs underway targeting chronic disease and other therapeutic areas. For more information, please visit http://www.durect.com.

Photo: NewsCom: http://www.newscom.com/cgi-bin/prnh/20020717/DRRXLOGOAP Archive: http://photoarchive.ap.orgPRN Photo Desk, +1-888-776-6555 or +1-212-782-2840DURECT Corporation

CONTACT: Matthew J. Hogan, Chief Financial Officer of DURECT Corporation,+1-408-777-4936; or media, Jeremiah Hall, Senior Vice President ofFeinstein Kean Healthcare, +1-415-677-2700, jeremiah.hall@fkhealth.com

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