DILIsym Services Partners with Large Pharmaceutical Company to Begin QSP Model Development for Heart Failure

This new venture represents the company’s first project focused on QSP for heart failure. DSS expects the resulting IP to enable a pipeline of heart failure-related consulting and licensing revenue in the future, expanding the company’s addressable market. More importantly, the project illustrates the willingness of DSS to partner with its clients to provide custom solutions to their modeling and simulation needs in the areas of both efficacy and safety.

Scott Siler, Chief Scientific Officer of DSS, noted: “This QSP modeling effort builds on our existing competencies in developing models of fibrosis and companion pathophysiologies. Simulating the mechanisms contributing to the development of cardiac fibrosis and its contributions to heart failure will enable us to support the pharmaceutical industry in the development of therapeutics to treat heart failure by predicting efficacy before real-world patients are administered potential drugs.”

Brett Howell, President of DSS, added: “We are well suited to serve the full spectrum of our clients’ QSP needs, such as the development of a custom heart failure-related application in this case. The pharmaceutical industry’s use of QSP modeling approaches to improve development decision making and outcomes is increasing rapidly. Building upon our success in developing DILIsym^®, the industry standard for liver safety modeling, we have applied our QSP expertise in an expanding array of therapeutic areas including NASH, pulmonary fibrosis, and now heart failure.”

About DILIsym Services Inc.

DILIsym Services Inc. was founded in 2015 in Research Triangle Park, North Carolina, and is the leading provider of drug-induced liver injury simulation software and related consulting services to the pharmaceutical industry. The company spun out of the former Hamner Institutes, acquiring all of the intellectual property, software, documentation, and other materials for the DILIsym software. The company’s other products include MITOsym^®, for simulating in vitro mitochondrial function; NAFLDsym^®, for the study of nonalcoholic fatty liver disease – a worldwide disease with few available treatment options; and future tools RENAsym™ for predicting drug-induced kidney injury and IPFsym™ for predicting the efficacy of drugs being developed to treat idiopathic pulmonary fibrosis (IPF). More information is available on the company’s website at https://www.dilisym.com.

About Simulations Plus, Inc.

Simulations Plus, Inc., is a premier developer of drug discovery and development software as well as a leading provider of both preclinical and clinical pharmacometric consulting services for regulatory submissions and quantitative systems pharmacology models for drug-induced liver injury and nonalcoholic fatty liver disease. The company is a global leader focused on improving the ways scientists use knowledge and data to predict the properties and outcomes of pharmaceutical, biotechnology, and chemical agents. Our software is licensed and used in the conduct of drug research by major pharmaceutical, biotechnology, chemical, and consumer goods companies and regulatory agencies worldwide. Our innovations in integrating new and existing science in medicinal chemistry, computational chemistry, pharmaceutical science, biology, and physiology into our software have made us the leading software provider for physiologically based pharmacokinetic modeling and simulation. For more information, visit our website at www.simulations-plus.com.

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