With its unique technique and years of experience in the field of antibody sequencing, Creative Biolabs is glad to release de novo antibody sequencing service.
Creative Biolabs is glad to show a series of comprehensive de novo antibody sequencing services based on its next generation antibody sequencing platform. All species, isotypes and allotypes of antibodies can be sequenced with 100% coverage.
“Numerous successful cases from Creative Biolabs have confirmed our qualification to provide antibody sequencing with 100% accuracy”, said Dr. Monika, scientific officer of Creative Biolabs.
It has overcome the current drawback of sequencing based on traditional methods and developed “Database Assisted Shotgun Sequencing” (DASS) technology, which provides de novo antibody sequencing services for research, diagnostic and therapeutic industries. Its services consist of variable region, variable plus leader region and full length heavy and light chain antibody sequencing for all species. Purified monoclonal antibody in multivalent forms can be sequenced with 100% coverage of the desired regions as well as accuracy.
DASS system provides reliable supporting proof for confirmation and validation of produced mAb, QC analysis and IND/NDA application.
Sequencing of Isobaric Amino Acids
In contrast to other MS based methods, Creative Biolabs can discriminate most isobaric amino acid combinations.
• W can be distinguished from GE, AD and SV (by mass difference) .
• R can be distinguished from GV (by mass difference) .
• Q can be distinguished from GA and K (by fragment spectra and mass difference) .
• N can be distinguished from GG (by derivatization and fragment spectra) .
• Leucine and isoleucine cannot be distinguished.
Other service specifications include sequencing of the V and J and C segments by DASS, de novo sequencing of the CDR3 region and sequencing of fluorochrome mABs, IgMs as well as other non-standard antibodies
About Creative Biolabs
Creative Biolabs is specialized in providing custom biotechnology and pharmaceutical services that cover the full scope of biotechnology needs of early antibody production and development.
