It is reported that Creative Biolabs has successfully updated its ADC platform with months of research.
Creative Biolabs is a biotech service provider located in Shirley, New York. It has been working in the field of antibody drug conjugate for years, aiming at bringing breakthroughs to antibody engineering and bio-pharmaceuticals.
ADCs are composed of antibodies and cytotoxic drugs and conjugated by chemical linkers. They combine the abilities of mAbs and cytotoxic drugs, improving the control of drug pharmacokinetics and allowing specific drug delivery to target cells. A number of ADCs have been researched and entered clinical trials in recent years.
The successful FDA approval of brentuximab vedotin (Adcetris®, SGN-35) and ado-trastuzumab emtansine (Kadcyla ®, T-DM1) further suggests that ADCs are promising therapeutic agents for oncotherapy.
“Our scientists from different disciplines, such as biochemical and chemistry, are working together to design and perform optimized processes in ADC development”, said Dr. XXX, scientific officer of Creative Biolabs.
With the ADC platform, Creative Biolabs can provide services like Antibody modification and conjugation, Payloads for ADCs, ADC analysis, ADC manufacture, etc.
It uses various strategies in antibody modification and conjugation, including Cysteine-based conjugation lysine-based conjugation, carbohydrate-based conjugation, unnatural amino acids-based conjugation, thio-engineered antibody and otehrs. In addition, it provides various toxins used as payloads to conjugate with antibodies to form ADCs. The analysis services of conjugate antibodies usually include biophysical/biochemical characterization, stability analysis, pharmacokinetics (PK) characterization, ADME characterization, DAR and drug distribution assessment. With various analytical methods, the characteristics of ADC are certified to facilitate the assessment of ADC function and make better ADC optimization.
About Creative Biolabs
Creative Biolabs is specialized in providing custom biotechnology and pharmaceutical services that cover the full scope of biotechnology needs of early drug discovery and drug development. As a trusted provider of the cost-effective outsourcing solutions, Creative Biolabs has been working for a large number of clients from biotechnology and pharmaceutical companies as well as government and academic research laboratories all over the world.
Contact
Bella Smith
Marketing Specialist
631-830-6441
marketing@creative-biolabs.com
