SAN ANTONIO--(BUSINESS WIRE)--Concert Pharmaceuticals, Inc. announced today the presentation of Phase 1 data on CTP-347, a deuterium-modified analog of paroxetine for the treatment of hot flashes. Concert presented the results during a poster session at the American College of Clinical Pharmacology’s 38th Annual Meeting. This presentation highlighted that subjects treated with CTP-347 substantially retained cytochrome P450 2D6 (CYP2D6) enzyme activity. This enzyme is necessary for the metabolism of many common drugs, but is irreversibly inactivated by a metabolite of paroxetine, causing significant drug-drug interactions. Concert believes these findings represent the first reported clinical data demonstrating that deuterium substitution can alter a drug’s metabolism to reduce the potential for drug-drug interactions in humans.
