LEXINGTON, Mass.--(BUSINESS WIRE)--Concert Pharmaceuticals, Inc. announced today positive Phase I clinical trial results of CTP-347, an investigational non-hormonal treatment for vasomotor symptoms (hot flashes). CTP-347, a novel deuterium-modified analog of paroxetine discovered at Concert, was well-tolerated at all doses. Paroxetine is a serotonin reuptake inhibitor that has been shown to reduce vasomotor symptoms. However, paroxetine inactivates the important liver enzyme CYP2D6 which can lead to serious side effects when used in combination with many common medications. In contrast, in this study, CTP-347 substantially retained the activity of this key enzyme, potentially enabling its broader use with other drugs. These clinical results confirm Concert’s preclinical observations. The Company expects to present the complete Phase 1 results at a future medical meeting in 2009.
