Staying up-to-date has never been simpler. Sign up for the free GenePool newsletter today!
Singapore – Surprise! Your morning cup of tea or coffee may be doing more than just perking you up before work.
An international team of researchers led by Duke-NUS Graduate Medical School (Duke-NUS) and the Duke University School of Medicine suggest that increased caffeine intake, may reduce fatty liver in people with non-alcoholic fatty liver disease (NAFLD).
Worldwide, 70 percent of people diagnosed with diabetes and obesity have NAFLD, the major cause of fatty liver not due to excessive alcohol consumption. Currently, it is estimated that 30 percent of American adults have this condition, and its prevalence is rising in Singapore. There are no effective treatments for NAFLD except diet and exercise.
Using cell culture and mouse models, the authors of the study, led by Paul Yen, M.D., associate professor and research fellow, Rohit Sinha, Ph.D of the Duke-NUS Graduate Medical School’s Cardiovascular and Metabolic Disorders Program in Singapore at Duke-NUS observed that caffeine stimulates the metabolization of lipids stored in liver cells and decreased the fatty liver of mice that were fed a high fat diet. Consequently, these findings suggested that coffee and tea consumption (equivalent to the caffeine intake of four cups a day) may be beneficial in the prevention and protection against the progression of NAFLD in humans.
The findings will be published in the September issue of the journal Hepatology.
“This is the first detailed study of the mechanism for caffeine action on lipids in liver and the results are very interesting,” said Yen. “Coffee and tea are so commonly consumed and the notion that they may be therapeutic, especially since they have a reputation for being “bad” for health, is especially enlightening.”
The team hopes that this research could lead to the development of caffeine-like drugs that do not have the usual side effects related to caffeine, but retain its therapeutic effects on the liver. It would serve as a starting point for studies on the full benefits of caffeine and related therapeutics in humans.
In addition to Yen and Sinha, collaborators included Christopher Newgard, PhD, director of the Sarah W. Stedman Nutrition and Metabolism Center at Duke University School of Medicine, where the metabolomics analysis of the data was conducted.
The study was supported by funding from Singapore’s Agency for Science, Technology, and Research; the Ministry of Health; and the Ministry of Education.
For media queries, please contact:
Ms Dharshini Subbiah
Duke-NUS Graduate Medical School Singapore
Email: dharshini.subbiah@duke-nus.edu.sg
Tel: (65) 6601-3272
About Duke-NUS Graduate Medical School
The Duke-NUS Graduate Medical School Singapore (Duke-NUS) was established in 2005 as a strategic collaboration between the Duke University School of Medicine, located in North Carolina, USA and the National University of Singapore (NUS). Duke-NUS offers a graduate entry, 4-year M.D. (Doctor of Medicine) training program based on the unique Duke model of education, with one year dedicated to independent study and research projects of a basic science or clinical nature. Duke-NUS also offers M.D/PhD and PhD programs. As a player in Singapore’s biomedical community, Duke-NUS has identified five Signature Research Programs: Cancer & Stem Cell Biology, Neuroscience and Behavioral Disorders, Emerging Infectious Diseases, Cardiovascular & Metabolic Disorders, and Health Services and Systems Research.
Duke-NUS and SingHealth, Singapore’s largest public healthcare group, have established a strategic partnership in academic medicine that will guide and promote the future of medicine, tapping on and combining the collective strengths of SingHealth’s clinical expertise and Duke-NUS’ biomedical sciences research and medical education capabilities.
For more information, please visit www.duke-nus.edu.sg
Help employers find you! Check out all the jobs and post your resume.
