CardioVascular BioTherapeutics, Inc. (OTCBB:CVBT) today announced it has signed a collaborative research agreement with Vance Gardner, M.D., executive director of the Orthopaedic Education and Research Institute of Southern California, to conduct a feasibility study in patients with chronic back pain caused by degenerative disc disease to determine if back pain is related to poor blood flow and decreased nutrition of the discs in the lower back.