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The extent of “folds” on the outer layer of the brain could give doctors a clue as to how well people suffering problems such as hallucinations or delusions will respond to antipsychotic drugs. Researchers using magnetic resonance imaging (MRI) scans of people with psychosis identified patterns of folds in the brain that could act as markers of whether a patient’s symptoms will be eased by medication. Since around half of young patients get little or no benefit from the first medicines prescribed after a psychotic episode, the scientists said the finding could help identify those at greatest risk and may also help the search for better drugs.
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