Biotica Technology Limited Extends License to Amyris for Polyketide Engineering Technology

CAMBRIDGE, UK (16 February 2011) – Biotica Technology Ltd. announces today that it has signed an agreement with Amyris, Inc. (NASDAQ: AMRS) under which Amyris obtains a non-exclusive license to Biotica’s polyketide engineering technology within its areas of business, including biofuels. Financial terms were not disclosed.

“Amyris is a leader in renewable specialty chemicals and transportation fuels and an ideal partner to use our polyketide engineering technology” commented Edward Hodgkin, Chief Executive Officer of Biotica.

“Biotica holds a dominant IP position in polyketide engineering technology, and we are delighted to be able to use their methods in our research” added Neil Renninger, Chief Technology Officer of Amyris.

In July 2010 Biotica acquired a portfolio of technology IP from Bristol-Myers Squibb Company (NYSE: BMY), including IP formerly controlled by Kosan Biosciences. The acquired IP, combined with Biotica’s substantial IP portfolio, gave Biotica a leading position in polyketide engineering. Amyris now has access to that technology IP. Biotica will continue to focus on polyketide therapeutics, taking advantage of its IP position to exploit the enormous potential of the polyketide opportunity.

About Biotica

Biotica is a privately-held biotechnology company that discovers and develops polyketide therapeutics. It has a growing pipeline of novel therapeutic programmes supported by clinical validation. These include nPT-mTOR (unique mTOR inhibitors partnered with Pfizer), nPT-CyP (cyclophilin inhibitors for HCV) and nPT-ery (anti-inflammatory erythromycin analogues partnered with GlaxoSmithKline). All of Biotica’s projects employ its proprietary novoPT™ technology, which enables it to select from the many known polyketides with biological activity and make a range of derivatives that are either difficult or impossible to make by medicinal chemistry methods. For additional information visit www.biotica.com.

For more information please contact:

Edward Hodgkin, CEO, Biotica Tel: +44 (0) 1799 532 923

Dr Lynne Trowbridge, Daniel Gooch, College Hill Tel: +44 (0) 20 7866 7866

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