Neuropore Therapies Commences Phase I Clinical Trials

• Neuropore Therapies Inc. commences Phase 1 clinical trials with NPT200-11; a potential new disease modifying treatment for Parkinson’s Disease
• This trial is a randomized, double blind placebo controlled clinical trial designed to evaluate safety, tolerability and pharmacokinetics of NPT200-11 in healthy subjects

SAN DIEGO--(BUSINESS WIRE)--Neuropore Therapies, Inc. announced today that it has commenced Phase 1 clinical trials with NPT200-11, a novel potential treatment for Parkinson’s Disease.

“We are pleased to have advanced NPT200-11 to first dose in man, a significant milestone in the development of this novel drug candidate. The decision to progress into Phase 1 follows several years of highly promising pre-clinical research”

“We are pleased to have advanced NPT200-11 to first dose in man, a significant milestone in the development of this novel drug candidate. The decision to progress into Phase 1 follows several years of highly promising pre-clinical research,” said Dieter Meier, Neuropore’s CEO. “We believe that NPT200-11 has the potential to become an important advancement in the treatment of Parkinson’s Disease and other synucleinopathies.”

As announced in January 2015, Neuropore Therapies entered into world-wide collaboration with UCB to develop and commercialize NPT200-11 in all indications. To date, Neuropore has received $20.5 million of the potential $460 million in total milestones through its collaboration with UCB.

Neuropore Therapies has conducted extensive research over the last seven years to develop novel therapeutic products aimed at slowing the progression of Parkinson’s disease and related disorders. The results of this effort include NPT200-11. Other scientifically novel approaches with preclinical stage drug-candidates are ongoing.

About Parkinson’s disease

Parkinson’s disease (PD) is the second most common neurodegenerative disorder after Alzheimer’s disease. There are an estimated seven to ten million patients with PD worldwide. Current treatments for PD are effective at managing the early motor symptoms of the disease, mainly through the use of levodopa and dopamine agonists. As the disease progresses and dopaminergic neurons continue to be lost, these drugs eventually become less effective at treating the symptoms.

About NPT200-11

By stabilizing conformations of alpha-synuclein that are then incapable of assembling into toxic pore-like oligomers in cell membranes, NPT200-11, blocks the pathological protein misfolding, aggregation and deposition that contribute to synaptic dysfunction and cell death in PD and related disorders. NPT200-11 is orally bioavailable, has promising drug-like properties and, has shown robust beneficial actions on multiple endpoints in animal models.

About Neuropore Therapies, Inc.

Neuropore Therapies is developing novel small molecule therapeutics to treat and slow the progression of neurodegenerative disorders such as Alzheimer’s and Parkinson’s disease. The approach being taken by Neuropore is to target an underlying pathological process common to these disorders – the accumulation of toxic oligomeric aggregates of misfolded neuronal proteins in cell membranes. By preventing the formation of these toxic aggregates synaptic function may be restored and neurodegenerative processes slowed.

Neuropore Therapies uses structure-based drug design and dynamic molecular modeling to identify key target regions on proteins that are important for the formation of toxic protein aggregates. Candidate compounds targeting these regions are then synthesized and evaluated in cell-free and cell-based assays systems. Promising compounds are then evaluated in various disease-related animal models. For more information visit www.neuropore.com

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