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Sleeping sickness kills tens of thousands of people in Africa each year. Current chemotherapies are subject to various limitations, including resistance. Rhodesain, an enzyme of the parasites that cause this illness (human African trypanosomiasis), has emerged as a target for new drug candidates. Scientists led by F. Diederich (ETH Zürich) studied the molecular recognition properties of rhodesain and developed a series of triazine nitrile inhibitors as lead compounds using structure-based molecular modeling.
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