NEW YORK--(BUSINESS WIRE)--Archer Biosciences, Inc. announced that the trial of its novel, proprietary drug TPI-287 (an abeotaxane) for the treatment of metastatic melanoma has initiated a third drug-escalation cohort. The primary objective of this study is to determine the safety, tolerability and maximum tolerated dose (MTD) of TPI-287 in combination with temozolomide (TMZ) in adult patients with metastatic melanoma. The study includes patients with disease metastatic to the brain as TPI-287, avoids the multidrug resistant (MDR) efflux pump and has demonstrated in pre-clinical studies its ability to cross the blood brain barrier.
