Aerie Announces Four New Abstracts To Be Presented At The American Glaucoma Society 26th Annual Meeting Next Week

IRVINE, Calif.--(BUSINESS WIRE)--Aerie Pharmaceuticals, Inc. (NASDAQ:AERI), a clinical-stage pharmaceutical company focused on the discovery, development, and commercialization of first-in-class therapies for glaucoma and other diseases of the eye, today announced that two paper abstracts and two poster abstracts are scheduled to be presented at the American Glaucoma Society (AGS) 26th Annual Meeting, taking place March 3-6, 2016, in Fort Lauderdale, Florida. These presentations provide additional insights into AR-13324, an active ingredient in both of Aerie’s advanced clinical-stage products, Rhopressa^TM (netarsudil ophthalmic solution) 0.02% and Roclatan^TM (netarsudil/latanoprost ophthalmic solution) 0.02%/0.005%. AR-13324 has recently been granted the USAN name “netarsudil.” The abstracts will be posted on Aerie’s website on March 3, 2016, including all investigator credits.

“Anti-fibrotic Effects of AR-13324 in a 3D Bioengineered Human Trabecular Meshwork Model”

Paper Abstracts:

• “Topical Administration of a ROCK/NET Inhibitor Promotes Retinal Ganglion Cell Survival and Axon Regeneration,” to be presented by Jeffrey Goldberg, M.D., Professor and Chair of Ophthalmology at the Byers Eye Institute at Stanford University
• “Anti-fibrotic Effects of AR-13324 in a 3D Bioengineered Human Trabecular Meshwork Model,” to be presented by Cheng-Wen Lin, Ph.D., Aerie Pharmaceuticals

Poster Abstracts:

• “The Mechanisms of Increasing Outflow Facility by AR-13324M in Human Eyes,” to be presented by Haiyan Gong, M.D., Ph.D., Professor of Ophthalmology and Anatomy and Neurobiology at Boston University
• “AR-13324 Ophthalmic Solution 0.02%: Topline Results of Two Phase 3 Clinical Studies in Patients with Open-Angle Glaucoma and Ocular Hypertension,” to be presented by Jason Bacharach, M.D., North Bay Eye Associates, Petaluma, CA

“These four abstracts provide meaningful insights into the differentiating characteristics of Rhopressa^TM. The abstracts include details associated with product attributes we have discussed in the past, including the potential effects of Rhopressa^TM on outflow mechanisms. In addition, for the first time promising new preclinical data supporting the neuroprotection potential of Rhopressa^TM will be presented,” said Vicente Anido, Jr., Ph.D., Chief Executive Officer and Chairman at Aerie.

About Aerie Pharmaceuticals, Inc.

Aerie is a clinical-stage pharmaceutical company focused on the discovery, development and commercialization of first-in-class therapies for the treatment of patients with glaucoma and other diseases of the eye. Aerie’s two lead product candidates are once-daiIy IOP-lowering therapies with novel mechanisms of action to treat patients with glaucoma and ocular hypertension. It is expected that the NDA filing for Rhopressa^TM (netarsudil ophthalmic solution) 0.02% will take place in the third quarter of 2016. The second product candidate, Roclatan^TM (netarsudil/latanoprost ophthalmic solution) 0.02%/0.005%, which is a fixed dose combination of Rhopressa^TM and widely prescribed PGA latanoprost, currently has one Phase 3 registration trial underway, named Mercury 1, with a second trial expected to commence in March 2016. If these trials are successful, a Roclatan^TM NDA filing is expected to take place in the second half of 2017. Aerie also announced in 2015 its research collaborations with GrayBug, Inc. and Ramot at Tel Aviv University as it further builds its pipeline for future growth.

Forward-Looking Statements

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