- SARS-CoV-2 IgG II Quant antibody test measures levels of IgG antibodies to help measure and understand a person’s immune response - The test specifically identifies levels of IgG antibodies that attach to the virus’ spike protein which can be helpful to evaluate a person’s immune response to vaccines
| ABBOTT PARK, Ill., Dec. 15, 2020 /PRNewswire/ --Abbott (NYSE: ABT) announced today it received CE Mark for its new quantitative SARS-CoV-2 IgG (Immunoglobulin G) lab-based serology test. IgG antibody testing that gives a quantitative result (measuring the amount of antibodies) provides important insights to people as they recover from COVID-19 and helps evaluate a person’s immune response to a vaccine. Countries around the world are preparing for the authorization and the distribution of COVID-19 vaccines. As these vaccines become available, healthcare professionals and researchers will need to assess how individuals and communities are responding. “Testing will continue to help both identify those who are infected as well as determine whether people have had a natural or vaccine-induced immune response,” said John Hackett, Ph.D., divisional vice president of Applied Research and Technology for Abbott’s diagnostics business. “Quantitative antibody testing can help provide greater understanding of a person’s immune response.” The evolution of serology testing during COVID-19 During the early months of the pandemic, Abbott launched its first COVID-19 IgG antibody blood test, which detects the nucleocapsid protein of the virus. The qualitative test continues to provide a better understanding of people’s immune response to the virus, including potential duration of the recovery process. The new quantitative antibody test expands on this knowledge by determining both the presence and level (or titer) of antibodies present in the blood. Abbott’s scientists designed its quantitative assay to detect the spike protein of the virus, which plays an important part in how the virus enters the cells. As the body develops an immune response, antibodies develop and bind to the spike portion of the virus in order to block the protein and ultimately prevent infection. Several vaccines are designed with the spike protein to trigger that same immune response. Research has also shown a correlation between rising IgG levels that target the spike protein, such as those in Abbott’s quantitative test, and rising levels of neutralizing antibodies, or the specific antibodies that block infections.1-2 Studies are underway to understand the relationship between the levels of antibodies a person has and potential immunity from the virus. As we continue to learn more about the virus, antibody tests may help:
The quantitative IgG antibody test is the latest in Abbott’s broad portfolio of tests to support the global healthcare community in the fight against COVID-19. Abbott’s COVID-19 test portfolio includes molecular, antigen and serology tests. These tests can help healthcare professionals detect the virus at all stages of its life cycle, including tests that are done in the lab as well as rapid tests done at the point of care. About the SARS-CoV-2 IgG II Quant antibody test A study to determine the clinical performance of Abbott’s SARS-CoV-2 IgG II Quant test on its Alinity i instrument found it had 99.60% specificity (ability to exclude false positives) and 99.35% sensitivity (ability to exclude false negatives) in patients tested 15 days or more after symptoms began. The quantitative IgG test will be available on both the Abbott ARCHITECT and Alinity i platforms. Abbott is also developing a test and plans to submit for U.S. Food and Drug Administration (FDA) emergency use authorization soon. About Abbott Connect with us at www.abbott.com, on LinkedIn at www.linkedin.com/company/abbott-/, on Facebook at www.facebook.com/Abbott and on Twitter @AbbottNews. References:
SOURCE Abbott | ||
Company Codes: NYSE:ABT |
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