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In the search for medication against Alzheimer’s disease, scientists have focused on -- among other factors -- drugs that can break down Amyloid beta (A-beta). After all, it is the accumulation of A-beta that causes the known plaques in the brains of Alzheimer’s patients. The starting point for the formation of A-beta is APP. Alessia Soldano and Bassem Hassan (VIB/KU Leuven) were the first to unravel the function of APPL -- the fruit-fly version of APP -- in the brain of healthy fruit flies.
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