Work Progresses Toward Anti-Aging Pill

In the latest report on a promising anti-aging strategy, scientists provide a detailed description of how a simple pill could one day help brains and other essential organs work better late in life.The pill would increase activity of a gene that produces molecules called sirtuins, which block the programmed process by which the body rids itself of aging cells, said Haim Y. Cohen, a senior research fellow at Harvard Medical School.A report in the June 18 issue of Science by Cohen and his colleagues focuses on the gene for one sirtuin, SIRT1. One study showed that rats fed a low-calorie diet produced more SIRT1 than those allowed to gorge themselves on unlimited food, the report said.

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