SANTA CLARA, CA--(Marketwire - August 20, 2008) - Symyx Technologies, Inc. (NASDAQ: SMMX) today announced joint releases of the Symyx Direct 6.1 chemistry data cartridge and ISIS/Host 5.2 informatics system for registering, retrieving, displaying and analyzing scientific information. These software upgrades -- coupled with the upcoming release of Symyx Isentris 3.1 informatics system -- remove a significant ISIS-to-Isentris transition barrier for R&D organizations working with legacy ISIS molecule databases. Symyx Direct 6.1 also enables ISIS customers to take advantage of advances in Symyx chemical representation, stereochemistry, and chemical fastsearch capabilities.