EurekAlert -- Breast cancer survivors continue to have a substantial risk of disease recurrence after five years of systemic therapy, according to a study published in the August 12 online issue of the Journal of the National Cancer Institute. Among breast cancer patients who were cancer-free five years after initiating systemic therapy, 89 percent remained recurrence-free at five years (approximately 10 years after a woman’s initial diagnosis) and 80 percent remained recurrence free at 10 years (approximately 15 years after diagnosis).