Rakovina Therapeutics Presents at the 6th biennial Canadian Cancer Research Conference

VANCOUVER, British Columbia, Nov. 11, 2021 (GLOBE NEWSWIRE) -- Rakovina Therapeutics Inc. (TSXV: RKV) (“the Company”), a biopharmaceutical company committed to advancing new cancer therapies based on novel DNA-damage response (DDR) technologies, today announced a summary of the Company’s presentation at the sixth biennial Canadian Cancer Research Conference (CCRC), being held virtually November 8-11, 2021.

Rakovina Therapeutics presented a poster presentation entitled In Vitro Activity of Novel Dual PARP-HDAC Inhibitors, which described results of the Company’s research related to the development of its novel kt-3000 series novel drug candidates. The Company will make its poster presentation available on its website following the conclusion of the meeting.

In summary, the data suggests promising activity for kt-3000 series compounds against both BRCA wild-type and BRCA mutant cancers, benchmarked against an FDA-approved PARP inhibitor.

PARP inhibitors target cancer cells with BRCA mutations by taking advantage of their reduced DNA-repair capacity to selectively kill cancer cells. An established mechanism of resistance to PARP inhibitors involves the restoration of BRCA1 or BRCA2 genes to their wild-type state. When a cancer cell is able to restore BRCA function, PARP-inhibitors become less effective.

“These preclinical data demonstrate that kt-3000 series drug candidates exhibit comparable activity to FDA-approved PARP inhibitors against BRCA-mutant cell lines, where PARP-inhibitors have demonstrated substantial clinical benefit in the treatment of BRCA-mutant breast and ovarian cancers,” stated Prof. Mads Daugaard, president & chief scientific officer of Rakovina Therapeutics. Importantly, select kt-3000 series drug candidates maintain their potency against BRCA-wild type cell lines in vitro where, as expected, the benchmark FDA-approved PARP inhibitor exhibits significantly reduced activity.”

“We continue to be pleased with progress in the development of the kt-3000 series. As a next step, we plan to advance the most promising lead compounds from this series into in vivo studies,” said Prof. Mads Daugaard. “We look forward to continuing to report our progress at upcoming scientific meetings.”

About Rakovina Therapeutics Inc.

Rakovina Therapeutics Inc. is focused on the development of new cancer treatments based on novel DNA-damage response (DDR) technologies. The Company has established a pipeline of DNA-damage response inhibitors with the goal of advancing one or more drug candidates into human clinical trials and obtaining marketing approval for new cancer therapeutics from Health Canada, the United States Food and Drug Administration and similar international regulatory agencies. Further information may be found at www.rakovinatherapeutics.com.

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