Protherics PLC - Major Interest in Shares

London, UK; Brentwood, TN, US: 16 March 2007 - Protherics PLC ("Protherics" or the "Company"), the international biopharmaceutical company focused on critical care and cancer, announces that the following notification of interest in the ordinary share capital of the Company was received on 15 March 2007 from M&G Investment Management Limited on behalf of Prudential plc pursuant to the Transparency Obligations Directive (Disclosure and Transparency Rules) Instrument 2006.
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