- ASGCT oral presentations to showcase recent development in engineering highly specific and potent CRISPR gene editing and epigenetic silencing technologies
- Late-breaking EAS oral presentation to report latest preclinical data for PCSK9-silencing therapy STX-1150 for ASCVD
ALAMEDA, Calif.--(BUSINESS WIRE)--#CRISPR--Scribe Therapeutics, Inc. (Scribe), a biotechnology company engineering purpose-built CRISPR technologies designed to reshape the treatment of disease by enabling earlier intervention, improved outcomes, and longer, healthier lives, today announced its participation in the 29th American Society of Gene & Cell Therapy (ASGCT) Annual Meeting and the 94th European Atherosclerosis Society (EAS) Congress.
Scribe will deliver two oral presentations and one workshop presentation at ASGCT, taking place May 11-15 at the Thomas Michael Menino Convention & Exhibition Center in Boston and virtually. The sessions will feature the company’s ongoing advances to its Epigenetic Long-Term X-Repressor (ELXR) and X-Editor (XE) genome editing technologies, including DeepXE, an AI-enabled CRISPR design platform for accurately predicting editing efficiency for Scribe’s XE-based therapeutics. Collectively, these data demonstrate Scribe’s ability to engineer CRISPR systems with enhanced specificity and potency. The ELXR presentation will feature recently published work describing the engineering and mechanism underlying the platform.
At the EAS Congress occurring May 24-27 at the Megaron Athens International Convention Centre in Greece, Scribe will deliver a late-breaking oral presentation on the preclinical data for STX-1150, its PCSK9-targeting epigenetic silencing therapy for low-density lipoprotein cholesterol (LDL-C) lowering.
Full abstracts are available on the ASGCT conference website. The presentation details for ASGCT and EAS are listed below.
ASGCT 2026 Annual Meeting, May 11-15 Oral Presentations
Workshop Title: Engineering CasX from clay to clinic: lessons in precision, potency, and translatability
Workshop Session: Advancing the next generation of tools for precision gene editing in vivo
Date: Monday, May 11, 2026
Time: 3:07 PM - 3:33 PM ET
Location: MCEC Room 052AB (Exhibit Level)
Speaker: Brett Staahl, Ph.D., Co-founder and VP of External Innovation
Title: Engineering CasX for therapeutic-grade in vivo editing with DeepXE, a predictive model for guide potency
Session: Genome editing III
Date: Friday, May 15, 2026
Time: 11:30 AM - 11:45 AM ET
Location: Westin Seaport Grand Ballroom AB (Concourse Level)
Speaker: Sarah Denny, Ph.D., Senior Director of Molecular Engineering
Abstract Number: 482
Title: ADDing a lock to epigenome editing: DNMT3A allostery enhances specificity and potency of CRISPR-CasX-based epigenetic repressors
Session: Expanding cell and gene therapy through therapeutic RNA and epigenome engineering
Date: Friday, May 15, 2026
Time: 3:45 PM - 4:00 PM ET
Location: MCEC Room 052AB (Exhibit Level)
Speaker: Emeric Charles, Ph.D., Senior Scientist
Abstract Number: 497
EAS Congress 2026, May 24-27 Late-Breaking Oral Presentation
Title: Epigenetic PCSK9 silencing with STX-1150 provides durable LDL-C control after a single dose
Session: Late breaker abstracts in PCSK9 pharmacology
Date: Monday, May 25, 2026
Time: 4:21 PM - 4:39 PM EET
Location: Aravanis Hall
Speaker: Benjamin Oakes, Ph.D., Co-founder and Chief Executive Officer
About Scribe Therapeutics
Scribe Therapeutics is a biotechnology company developing optimized in vivo CRISPR-based technologies and genetic medicines designed to become standard of care treatments for patients suffering from highly prevalent diseases, starting with cardiometabolic disease. Leveraging its CRISPR by Design™ approach and nature’s blueprint for improved cardiovascular health, Scribe’s initial programs focus on addressing the key drivers of ASCVD such as elevated LDL-C, lipoprotein(a), and triglycerides. The company’s lead candidate, STX-1150, is a novel liver-targeted therapy designed to epigenetically silence the PCSK9 gene and reduce LDL-C levels without inducing permanent DNA changes. To broaden and accelerate the impact of its engineered CRISPR technologies for patients, Scribe has formed strategic collaborations with world-leading pharmaceutical companies including Sanofi and Eli Lilly. Co-founded by Nobel Prize winner Jennifer Doudna and backed by leading life sciences investors, Scribe is advancing scalable, transformative, and preventative genetic medicines with the goal of improving outcomes and democratizing access to the protective effects of beneficial human genetics. To learn more, visit www.scribetx.com.
Contacts
Media Contact:
Thermal for Scribe Therapeutics
media@scribetx.com
