Potential New Target For Treatment Of Solid Tumors In Children

ScienceDaily (Apr. 16, 2008) — Australian researchers have identified a potential new target for treatment of neuroblastoma, the most common solid tumor among young children. The treatment involves inhibiting the production of ornithine decarboxylase (ODC1), a gene driven by the MYCN oncogene that is a powerful predictor of death from this disease. Researchers report that ODC1 inhibition delayed or prevented the development of neuroblastoma in a clinically relevant animal model, suggesting that suppressing ODC1 could be target for treating this cancer.

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