DANBURY, Conn.--(BUSINESS WIRE)--Perosphere Inc. announced today that it has entered into a third clinical trial collaboration agreement with Daiichi Sankyo, Inc. to study PER977, Perosphere’s investigational anticoagulant reversal agent, in phase 3 registration studies with edoxaban, Daiichi Sankyo’s investigational oral, once-daily, direct factor Xa-inhibitor. PER977 is a synthetic, small new molecular entity being developed by Perosphere that has been shown in preclinical and phase 1 and phase 2 clinical studies to directly bind to heparins as well as circulating direct factor Xa- and IIa-inhibitors reversing their anticoagulant effect. PER977 does not bind to blood coagulation factors or other blood proteins. In healthy volunteers, PER977 reverses anticoagulant activity after a single intravenous administration of 100 mg to 300 mg and does not require an extended infusion in order to maintain the reversal.
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