Most Antidepressants Miss Key Target of Clinical Depression, Centre for Addiction and Mental Health (CAMH) Study Finds

Centre for Addiction and Mental Health -- For Immediate Release - December 7 – TORONTO – A key brain protein called monoamine oxidase A (MAO-A) – is highly elevated during clinical depression yet is unaffected by treatment with commonly used antidepressants, according to an important study published today in the Archives of General Psychiatry. The study has important implications for our understanding of why antidepressants don’t always work.

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