Indivior PLC (LON: INDV) today announced the acceptance of seven abstracts for presentation at the 84th Annual Scientific Meeting of the College on Problems of Drug Dependence (CPDD) taking place June 11-15, 2022 in Minneapolis, MN.
| RICHMOND, Va., June 9, 2022 /PRNewswire/ -- Indivior PLC (LON: INDV) today announced the acceptance of seven abstracts for presentation at the 84th Annual Scientific Meeting of the College on Problems of Drug Dependence (CPDD) taking place June 11-15, 2022 in Minneapolis, MN.
Data to be presented include: a modelling study to characterize buprenorphine-fentanyl interaction and its effect on respiratory depression; pharmacokinetic simulations of transition from transmucosal buprenorphine to SUBLOCADE® (buprenorphine extended-release) injection; novel dimensions of recovery as well as the impact of pain on recovery , both based on data from the RECOVER–LT (Remission from Chronic Opioid Use-Studying Environmental and SocioEconomic Factors on Recovery – Long-Term [NCT04577144]) study; motivations for buprenorphine misuse in opioid use disorder (OUD); and an analysis of OUD symptom subtypes and treatment patterns.1-6 Lastly, clinical Phase 1 data will be presented on INDV-2000, an oral, highly potent, selective Orexin-1 receptor (OX1R) antagonist currently under investigation as a non-opioid medication for the treatment of opioid use disorder.7 “These data help us better understand OUD treatment and recovery, as well as the role of long-acting treatments,” said Christian Heidbreder, Chief Scientific Officer, Indivior. “The data presented provide new insights into how patients with opioid use disorder are managing therapeutic challenges while undergoing treatment.” Details of the data presentations: Poster Presentation Title: Modelling Buprenorphine Mitigation of Fentanyl-Induced Respiratory Poster Presentation Title: Transition of Patients Established on Long–Term Transmucosal Buprenorphine Poster Presentation Title: Long-Term Recovery From Opioid Use Disorder: Identification of Recovery Subgroups and Their Association With Opioid Use, Treatment, and Quality of Life Authors: Allison Tegge, William Craft, Hwasoo Shin, Diana Keith, Liqa Athamneh, Jeff Stein, Marco Ferreira, Howard Chilcoat, Anne Le Moigne, Angela DeVeaugh-Geiss, Warren Bickel Poster Presentation Title: Pain in Recovery From Opioid Use Disorder: The Importance of Acute and Poster Presentation Title: Buprenorphine Misuse in Opioid Use Disorders: Subgroups, Motivations, and Poster Presentation Title: Opioid Use Disorder (OUD) and Treatment for Opioid Problems Among OUD Poster Presentation Title: First in Human Trial of the Non-Opioid Selective Orexin-1 Antagonist INDV- About SUBLOCADE® INDICATION SUBLOCADE should be used as part of a complete treatment plan that includes counseling and
Prescription use of this product is limited under the Drug Addiction Treatment Act. CONTRAINDICATIONS WARNINGS AND PRECAUTIONS Respiratory Depression: Life threatening respiratory depression and death have occurred in association with buprenorphine. Warn patients of the potential danger of self-administration of benzodiazepines or other CNS depressants while under treatment with SUBLOCADE. Opioids can cause sleep-related breathing disorders e.g., central sleep apnea (CSA), sleep-related hypoxemia. Opioid use increases the risk of CSA in a dose-dependent fashion. Consider decreasing the opioid using best practices for opioid taper if CSA occurs. Strongly consider prescribing naloxone at SUBLOCADE initiation or renewal because patients being treated for opioid use disorder have the potential for relapse, putting them at risk for opioid overdose. Educate patients and caregivers on how to recognize respiratory depression and how to treat with naloxone if prescribed. Risk of Serious Injection Site Reactions: The most common injection site reactions are pain, erythema and pruritis with some involving abscess, ulceration, and necrosis. The likelihood of serious injection site reactions may increase with inadvertent intramuscular or intradermal administration. Neonatal Opioid Withdrawal Syndrome: Neonatal opioid withdrawal syndrome is an expected and treatable outcome of prolonged use of opioids during pregnancy. Adrenal Insufficiency: If diagnosed, treat with physiologic replacement of corticosteroids, and wean patient off the opioid. Risk of Opioid Withdrawal With Abrupt Discontinuation: If treatment with SUBLOCADE is discontinued, monitor patients for several months for withdrawal and treat appropriately. Risk of Hepatitis, Hepatic Events: Monitor liver function tests prior to and during treatment. Risk of Withdrawal in Patients Dependent on Full Agonist Opioids: Verify that patient is clinically stable on transmucosal buprenorphine before injecting SUBLOCADE. Treatment of Emergent Acute Pain: Treat pain with a non-opioid analgesic whenever possible. If opioid therapy is required, monitor patients closely because higher doses may be required for analgesic effect. ADVERSE REACTIONS For more information about SUBLOCADE, the full Prescribing Information including BOXED WARNING, and Medication Guide, visit www.sublocade.com. About Opioid Use Disorder (OUD) Opioid Use Disorder (OUD) is a chronic disease in which people develop a pattern of using opioids that can lead to negative consequences.8 OUD may affect the parts of the brain that are necessary for life-sustaining functions.8 About Indivior Indivior is a global pharmaceutical company working to help change patients’ lives by developing medicines to treat addiction and serious mental illnesses. Our vision is that all patients around the world will have access to evidence-based treatment for the chronic conditions and co-occurring disorders of SUD. Indivior is dedicated to transforming SUD from a global human crisis to a recognized and treated chronic disease. Building on its global portfolio of OUD treatments, Indivior has a pipeline of product candidates designed to both expand on its heritage in this category and potentially address other chronic conditions and co-occurring disorders of SUD, including alcohol use disorder and cannabis use disorder. Headquartered in the United States in Richmond, VA, Indivior employs more than 900 individuals globally and its portfolio of products is available in over 40 countries worldwide. Visit www.indivior.com to learn more. Connect with Indivior on LinkedIn by visiting www.linkedin.com/company/indivior. References:
SOURCE Indivior | ||||
Company Codes: LSE:INDV, OTC-PINK:INVVY |
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