Building on previous evidence supporting the theory that the pathophysiology of Crohn’s Disease is altered by genetic variation, recent studies have found that the combination of immune signals given by three variants of a single candidate gene affects the severity of the disease, particularly among Ashkenazi Jews. The findings, presented at the annual meeting of the American Gastroenterological Association, were reported by researchers from Cedars-Sinai Medical Center, the University of Washington and Mount Sinai School of Medicine.
