PENZBERG, Germany--(BUSINESS WIRE)--Promoter hypermethylation is a frequent mechanism for the repression of gene transcription in cancer and is regarded as one of the hallmarks of cancer. Analysis of DNA methylation is a promising tool for early cancer detection, risk assessment, and response to therapy. In a recent study (1), quantitative high-resolution melting analysis (HRM) with the Roche (Pink Sheets: RHHBY) (SWX:RO) (SWX:ROG) LightCycler Instrument was used for promoter methylation for analysis of formalin-fixed paraffin-embedded (FFPE) tissues. Since FFPE tissue samples are the largest source of material from normal controls and diseased tissues, their use is of inestimable value for research. Methodical evaluations are of high importance for demonstrating robustness and sensitivity of the assay, thus facilitating its establishment as a research tool and possibly a future routine test.
