Helix Biopharma Responds To Penta’s January 11, 2007 Press Release

AURORA, ON, Jan. 12 /PRNewswire-FirstCall/ - Helix BioPharma Corp.

The press release most recently issued by International Penta is merely a reiteration of Mr. Janssen’s previous complaints which have already been addressed by Helix in its press release and Letter to Shareholders dated January 10, 2007, filed at www.sedar.com and at www.helixbiopharma.com. A copy of Helix’s press release and Letter to Shareholders can be obtained by calling Georgeson at the contact numbers set out below.

Institutional Shareholder Services (ISS), the world’s leading provider of proxy voting and corporate governance solutions to the international marketplace, has observed that the proposed private placement is in the ordinary course of business, and is also in compliance with the rules of the Toronto Stock Exchange. ISS has recommended that Helix shareholders vote their YELLOW Helix proxy FOR the private placement and FOR the election of Jerome F. McElroy, Donald H. Segal, Kenneth A. Cawkell, Conor Gunne, Richard Rossman, Jack Kay and Gordon M. Lickrish.

As Helix has previously noted, the finder’s fee agreement which one of Mr. Janssen’s associated companies had with Helix expired on December 1, 2006. Prior to expiry of the agreement, Mr. Janssen proposed several financings to the Company with no reservations with respect to the dilution of existing shareholders.

------------------------------------------------------------------------- VOTE YOUR YELLOW HELIX PROXY NOW DO NOT VOTE A BLUE PROXY IF YOU HAVE ALREADY VOTED A BLUE PROXY, YOU CAN REVOKE IT BY SENDING IN A YELLOW HELIX PROXY NOW -------------------------------------------------------------------------

Helix recommends that all shareholders vote only their YELLOW Helix proxy FOR the private placement and FOR the election of Jerome F. McElroy, Donald H. Segal, Kenneth A. Cawkell, Conor Gunne, Richard Rossman, Jack Kay and Gordon M. Lickrish.

MAKE YOUR VOTE COUNT. PLEASE SIGN, DATE AND RETURN YOUR YELLOW PROXY BY JANUARY 19, 2007 AT 10:00 AM TORONTO TIME (EST) FOR YOUR VOTE TO COUNT.

A copy of Helix BioPharma’s current Annual Report and Management Information Circular for the January 23, 2007 meeting can be found on SEDAR at www.sedar.com, and at Helix’s website at www.helixbiopharma.com. Requests for a hard copy of the Annual Report or Management Information Circular can also be made to Georgeson.

Georgeson North American Toll Free Number: 1-866-288-9745 Outside North America Collect: +1-416-642-7018 (x)Toll Free - European: 00800 1020 1010 European Collect: +44 (0) 117 378 5993 (x)Australia; Austria; Belgium; Denmark; Finland; France; Germany; Hong Kong; Ireland; Israel; Italy; Netherlands; New Zealand; Norway; Spain; Sweden; Switzerland; Thailand; United Kingdom Please visit our website for regular updates at www.helixbiopharma.com

Helix BioPharma Corp.

CONTACT: and assistance in completing your YELLOW Helix proxy, please callGeorgeson, Helix’s proxy solicitor: North American toll free number1-866-288-9745, European(x) toll free number 00800-1020-1010; Collect callsoutside North America can be made at (416) 642-7018 or +44(0)117-378-5993