Ed Lewis, a 1995 Nobel Prize winner for his studies into how genes regulate development of specific regions of the body, has died of cancer. He was 86. Lewis died Wednesday at Huntington Hospital, the California Institute of Technology said Thursday. A member of the Caltech faculty since 1946, Lewis spent his career working on the genetics of the fruit fly. He specialized in the fundamental ways that genes relate to embryonic development. The work had profound implications for a basic understanding of the genetic regulation of development in humans, Caltech said.