A gene that’s normally switched off after fulfilling its role in brain development appears linked to a common childhood brain cancer, says a study in the Feb. 1 issue of Cancer Research.The study found that multiple extra copies of this gene, called OTX2, had been switched back on in tumor cells taken from children with medulloblastoma, the most common form of pediatric brain cancer. Medulloblastoma accounts for nearly a third of all brain tumors occurring in children in the United States.The scientists also found that trans-retinoic acid (ATRA), a powerful derivative of vitamin A, suppressed growth and induced death in tumor cells carrying switched-on OTX2. Treatment with ATRA had an effect on more than half of medulloblastomas grown in the laboratory.
