SCIENTISTS have mapped patterns of tiny DNA differences that distinguish one person from another, a step that will speed up the search for genes that promote common illnesses such as heart disease and diabetes. The map represents “a real sea change in how we study the genetics of disease,” said Dr David Altshuler, a leader of the project that included more than 200 researchers from six nations. Scientists want to find disease-related genes as a means for diagnosis, prediction and developing treatments. Such genes give clues to the biological underpinnings of disease, and so suggest strategies for developing therapies. Genes that predispose people to common disorders — heart disease, cancer, diabetes, asthma and others — are devilishly hard to find. But the new “HapMap” — taken from the genetics term, haplotype — opens the door to launching comprehensive searches through the human DNA for those genes, said Altshuler, who does research at the Broad Institute, which is a collaboration of Harvard and the Massachusetts Institute of Technology, and at Massachusetts General Hospital. HapMap data already have been used to track down a gene linked to the eye disorder macular degeneration, said HapMap project participant Dr Lincoln Stein of the Cold Spring Harbor Laboratory in New York. The map is described in today’s issue of the journal Nature. Participating scientists came from Canada, China, Japan, Nigeria, the United Kingdom and the United States. The project analyzed DNA samples from 269 people from Nigeria, Beijing, Tokyo and Utah.
