POMONA, Calif.--(BUSINESS WIRE)--Use of a controversial new cholesterol-lowering drug, ezetimibe (trade names: Zetia, Ezetrol, Vytorin), has increased in the United States, far beyond that seen in Canada, where direct-to-consumer advertising (DTCA) is prohibited and there is more government regulation of drug reimbursement in publicly-funded drug formularies. Worldwide sales for ezetimibe is estimated at $5 billion in 2007.