GENEVA--(BUSINESS WIRE)--Exelixis, Inc. (Nasdaq:EXEL) today reported preliminary phase 1 data from a dose-escalation trial of XL228 in patients with advanced malignancies (solid tumors, lymphoma, or multiple myeloma) for which standard therapies are no longer effective. XL228 is a potent small molecule inhibitor of insulin-like growth factor type 1 receptor (IGF1R) and SRC, which are protein kinases known to promote cancer cell survival, proliferation, and migration. XL228 also inhibits BCR-ABL, a protein kinase associated with chronic myelogenous leukemia (CML). Carolyn Britten, MD, Associate Professor and Director of the Phase 1 Oncology Program, UCLA Jonsson Comprehensive Cancer Center, and an investigator on the phase 1 trial, presented the data in a poster session (Abstract #390) at the EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics, which is being held October 21-24 in Geneva, Switzerland. The poster will be available today on the Exelixis web site.
