Endo Pharmaceuticals Comments on Notices Received From Anesiva, Inc.

CHADDS FORD, PA -- (MARKET WIRE) -- April 10, 2007 -- Endo Pharmaceuticals Inc., a wholly owned subsidiary of Endo Pharmaceuticals Holdings Inc. (NASDAQ: ENDP), announced today that it received notice from Anesiva, Incorporated, advising of the filing of a New Drug Application (NDA) under 21 U.S.C. § 355(b)(2)(A)(iv) (also referred to as Section 505 (b)(2)(A)(iv) of the Federal Food, Drug and Cosmetic Act) for its Zingo™ Dermal PowderJect Lidocaine HCl topical powder and referring to the patents that cover the method of use and formulation of Endo’s lidocaine-containing topical patch products, Lidoderm® and Synera™. Section 505(b)(2) does not allow for automatic generic substitution of these prescription products for any other products.

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