Pretreating the site of intradermal vaccination - vaccine delivered into the skin rather than to muscles beneath the skin - with a particular wavelength of laser light may substantially improve vaccine effectiveness without the adverse effects of chemical additives currently used to boost vaccine efficacy. In the open-access journal PLOS ONE, investigators from Vaccine and Immunotherapy Center in the Massachusetts General Hospital (MGH) Division of Infectious Diseases report that a one-minute dose of near-infrared laser light significantly improved the effectiveness of intradermal influenza vaccination in a mouse model - increasing both immune system activity and the animals’ survival.
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