Sittard/Leiden, The Netherlands, and Oeiras, Portugal January 5, 2006 - DSM Biologics, a business unit of DSM Pharmaceutical Products and Dutch biotechnology partner Crucell N.V. (Euronext, NASDAQ: CRXL; Swiss Exchange: CRX) announced today that they have signed a PER.C6® license agreement with pioneering and leading Portuguese biotechnology company, Biotecnol SA, and its USA based subsidiary Biotecnol, Inc. This license agreement allows Biotecnol to use the PER.C6® human cell line for preclinical and phase 1 clinical development of its proprietary antibody products, which are composed of Tribodies™ and Compact Antibodies.