A pharmaceutical company has suggested that the addition of a phosphorylated variant of gamma-tocopherol to lycopene-rich foods like tomato sauce might boost the carotenoid’s anti-cancer activity.Australia’s Phosphagenics developed GTP-0805 using its phosphorylation technology base to enhance the bioavailability of drugs and improve absorption through the gastrointestinal tract or skin. Not only have laboratory tests found that the compound induced a greater than 90 per cent reduction in breast and prostate cancer cells, but the company says it also demonstrated a synergistic anti-cancer affect on prostate cancer cells when combined with the antioxidant carotenoid lycopene. “Commercially, GTP-0805 may offer a number of product differentiation opportunities for multinational and functional food producers,” said the company. The compound, which claims to destroy diseased cells while not affecting normal ones by primarily acting as a signalling molecule and modulator of cancer pathways, is presently a drug candidate. Phosphagenics has announced the start of animal studies on the compound – an early stage along the road towards regulatory approval. The company has not given any details of any steps that have been taken towards approval of GTP-0805 for food use, but it would most likely need to be granted novel food status in Europe and GRAS (generally recognized as safe) status in the US. The proposed animal studies will assess the anti-cancer properties of GTP-0805 both alone and in combination with lycopene or with an anti-cancer drug, it being common practice to use combination therapy in the treatment of cancer. Phosphagenics’ earlier data, carried out by the Malaysian Palm Oil Board, suggested that GTP-0805 could enhance the absorption and intracellular uptake of cancer drugs, potentially minimising both the doses required and the adverse effects of cytotoxic drug therapies. The potential market for GTP-0805 as a cancer therapy product is believed to be significant with global sales of current breast cancer treatments estimated to be greater than $2 billion (€1.6 billion) per annum. No projects have been made for its potential in the functional foods arena. Previous laboratory studies on GTP-0805 found that the compound induced a greater than 90 per cent reduction in breast and prostate cancer cells.
