A microfluidic device developed at Massachusetts General Hospital (MGH) may help study key steps in the process by which cancer cells break off from a primary tumor to invade other tissues and form metastases. In their report published in Nature Materials, the investigators describe an stands for epithelial-mesenchymal transition, a fundamental change in cellular characteristics that has been associated with the ability of tumor cells to migrate and invade other sites in the body. Therapies that target this process may be able to slow or halt tumor metastasis.
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