SAN FRANCISCO--(BUSINESS WIRE)--Scientists at Duquesne University and the Medical University of South Carolina report in the on line version of the Journal of Medicinal Chemistry (50,3290,2007) on novel compounds with potent anti-tumor activity, which are also active on cancer cells resistant to other anti-tumor agents. Many tumors develop resistance to chemotherapeutic agents such as paclitaxol by producing protein pumps, such as p-glycoprotein, which expel the cancer drugs which penetrate into the tumor cells. Thus, the level of cancer drug is reduced and the cancer cell escapes. The development of drug resistance is a critical event in cancer removing therapeutic options.
