Could Big Pharma’s Appetite Hurt Independents?

Those sounds you hear reverberating through the local biotech industry are the heavy footsteps of Big Pharma.

Uncorking its plan to buy Lexington’s Cubist Pharmaceuticals Inc. for $9.5 billion last week, New Jersey-based Merck & Co. became the latest drug giant to expand its presence here. Global players such as Pfizer Inc., Novartis AG, Sanofi SA, Takeda Pharmaceutical Co., and Shire PLC have all planted a stake in the Boston area, mostly by gobbling up strong homegrown biotechs.

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