Chemomab Therapeutics Ltd. (Nasdaq: CMMB), (Chemomab) today announced that the Patent Offices in Brazil and Israel have granted new patents for CM-101, Chemomab’s first-in-class monoclonal antibody that neutralizes CCL24, a novel disease target that has been shown to play a critical role in the processes that drive diseases involving fibrosis and inflammation.
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[20-February-2024] |
—CM-101 Phase 2 Trial for the Treatment of Primary Sclerosing Cholangitis (PSC) Has Completed Patient Enrollment with Topline Data Expected Midyear 2024— —New CM-101 Patents Granted by Brazil and Israel Provide Additional Protections for Composition of Matter and for Use in Fibrotic Diseases of the Liver, including PSC— —Further Extend Protections Afforded by Multiple CM-101 Patents that Have Issued in the U.S., Europe, Israel and Related Territories— TEL AVIV, Israel, Feb. 20, 2024 /PRNewswire/ -- Chemomab Therapeutics Ltd. (Nasdaq: CMMB), (Chemomab), a clinical stage biotechnology company developing innovative therapeutics for fibro-inflammatory diseases with high unmet need, today announced that the Patent Offices in Brazil and Israel have granted new patents for CM-101, Chemomab's first-in-class monoclonal antibody that neutralizes CCL24, a novel disease target that has been shown to play a critical role in the processes that drive diseases involving fibrosis and inflammation. CM-101 is currently being assessed in the global Phase 2 SPRING trial for the treatment of primary sclerosing cholangitis (PSC). Patient enrollment in the trial has been completed, with a topline data readout expected midyear 2024. The Brazilian composition of matter Patent No. BR 11 2016 020366 6 "Anti Eotaxin-2 Antibodies That Recognize Additional CCR3-Binding Chemokines" includes claims broadly covering CM-101 and related anti-CCL24 antibodies per se and specifically for the treatment of fibrotic, inflammatory and autoimmune diseases. The grant of the patent was published January 2, 2024, with corresponding first to expire claims in 2035. Israeli Patent No. 269094 "Anti CCL24 (Eotaxin2) Antibodies for Use in the Treatment of Hepatic Diseases" covers the use of CM-101 in the treatment of hepatic (liver) diseases, including PSC. It has a grant date of February 2, 2024, with corresponding first to expire claims in 2038. The new patent supplements existing Israeli CM-101 composition of matter and related patents. PSC is a potentially lethal condition that lacks any FDA-approved therapies and frequently requires liver transplantation. Unlike the other drugs in development for PSC, CM-101 has a unique dual mechanism of action that simultaneously blocks fibrosis and inflammation. In clinical and preclinical studies, this distinctive approach has been shown to inhibit fibrogenesis and interfere with core PSC pathways. "These new patents add to the robust intellectual property protections we have secured for CM-101, with multiple patents issued and allowed in the U.S., European Union, Israel, and other major territories," said Adi Mor, PhD, co-founder, Chief Executive Officer and Chief Scientific Officer of Chemomab. "This is an exciting time at Chemomab as we prepare for the release of topline data from our Phase 2 PSC trial, which offers the first substantial clinical proof-of-concept of CM-101's therapeutic activity and represents a potential major catalyst for the company." In combination with the five families of CM-101 composition of matter and use patents that are either issued or pending in major territories worldwide, these new patents are expected to provide protection of CM-101 across a number of indications until 2038, with the possibility of up to five years extension upon market approval. CM-101 has been granted Orphan Drug designation in the U.S. and the E.U. and the FDA recently awarded CM-101 Fast Track designation for the treatment of PSC in adults. About CM-101 About Chemomab Therapeutics Ltd. Forward Looking Statements Contacts: Media and Investors:
SOURCE Chemomab Therapeutics Ltd |
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Company Codes: NASDAQ-NMS:CMMB |