On April 24, 2019, BOC Sciences, a New York- based chemical company announces to launch a fast hit identification service through various methods and techniques like NMR, X-ray crystallography and HTS for the science community in its lead discovery efforts.
On April 24, 2019, BOC Sciences, a New York- based chemical company announces to launch a fast hit identification service through various methods and techniques like NMR, X-ray crystallography and HTS for the science community in its lead discovery efforts.
Pharmaceutical development is an extremely complex process which involves discovery of innovative active ingredients all the way to the launch of a finished product. It is costly and often takes more than a decade before the final success. During this process, hit identification for the discovery of lead compounds are the initial research and largely determines whether the drug development would come out as a success or not.
“The very first step for researchers is to look for molecules of high specificity with an adequate activity in a suitable target assay, which could become potential initial leads,” says Mr. Barron Jones, the Marketing Chief of BOC Sciences. “We need to employ different methods to identify proprietary, synthetically tractable and pharmacologically relevant compounds in a fast manner.”
There are quite a number of approaches or strategies that could be used to deliver high-quality, validated hits. For example, techniques such as nuclear magnetic resonance (NMR) and X-ray crystallography require very detailed ligand and/or target information. However, there are also strategies that do not require any prior information on target or ligand, which generally use serendipity-based search strategies in either a given physical or virtual compound subset. With the help of high-throughput screening (HTS), such random hit-identification strategies are made possible.
Mr. Barron Jones further explains these three methods, “NMR spectroscopy is a useful tool in the hit identification, which has been widely applied to detect ligand binding and to monitor enzyme kinetics and inhibition. X-ray crystallography is a technique developed to analyze the atomic and molecular structures of crystals, and the structural information obtained is then used to evolve the fragments to hits, either by growing the fragment or combining structural features from a lot of compounds. HTS, widely used in drug discovery, is a scientific method that can help identify hits, antibodies, or genes that regulate a specific biological pathway.”
These high quality hits identified by BOC Sciences are the starting point of drug design and can make faster progress in drug discovery project with lower attrition rates. For more information about BOC Sciences’ hit identification and lead optimization service, please visit: https://www.bocsci.com/solutions/hit-identification.htm.
About BOC Sciences
Dedicated to become a trust-worthy brand, BOC Sciences strives to offer strategies and solutions to assist in the resolution of the industry’s most pressing drug development issues. To this end, it provides comprehensive medicinal chemistry services, custom synthesis, analysis/purification, formulation services for pharmaceutical companies engaged in drug discovery and research.
