BioTie Therapies Corp. Notification according to Chapter 2, Section 10 of the Finnish Securities Market Act relating to Decrease in Holdings

Biotie Therapies Corp. (“Company”) has gained knowledge of the notification regarding the following changes in holdings in accordance with Chapter 2, Section 9 of the Finnish Securities Markets Act. The change (decrease below 1/10 of total number of shares) in holdings relate to the increase in the total number of shares in the Company as a result of the directed share offering registered on 14 December 2009.

TVM Life Science Ventures VI GmbH & Co. KG has notified that as a result of the Company issuing 14,432,000 new shares in the directed offering as registered on December 14, 2009, their holdings has decreased below 1/10 to 9.64% of total number of shares and votes in the Company.

The holdings in accordance with Chapter 2, Section 9 of the Finnish Securities Markets Act of which the Company has gained knowledge is described below.

The registered number of shares in Biotie Therapies Corp. is 158,752,560 and the number of voting rights attached to the shares amounts to 158,289,305.

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