Royston, UK (11 March 2009) – Syrris, a leading chemistry automation product innovator, has introduced the new Atlas SonoLab™ System in collaboration with Prosonix, a world leader in patented sonocrystallization technology. The Atlas SonoLab System is a high-performance, automated ultrasound system for sonocrystallization, sonomilling and sonochemistry. Combining the Atlas jacketed reactor platform with Prosonix’s new SonoLab ultrasound technology enables the reproducible control of crystallizations and allows selectivity of parameters such as particle size, shape, crystallinity and polymorph.
With advanced control of nucleation and growth rate, the Atlas SonoLab System is able to produce extremely pure results for a high-quality final product. Batch-to-batch consistency is maintained via automated control of the process parameters and nucleation, to provide extremely reproducible results. Controlling nucleation without using external seed crystals avoids any consistency issues and increases selectivity. Furthermore, utilising the new SonoLab equipment in conjunction with the Atlas platform provides a basis for quality ultrasonic experiments and a seamless transition from laboratory to pilot plant at scales ranging from 100 ml to 100 L. In addition, laboratory results can be successfully implemented at manufacturing scale using the Prosonitron™ range of instruments.
The easy-to-use Atlas SonoLab system incorporates the Atlas Software’s intuitive “drag and drop” user interface with the ability to produce real-time graphs as the experiment occurs. An accurate process performance is provided using the sophisticated proportional-integral-derivative (PID) temperature control with accurate sensor feedback to ensure optimal temperatures are maintained through-out. Furthermore, the Atlas Software allows the introduction of ultrasound at accurate temperature points within and around the metastable zone enabling complete control of all important parameters required for sonocrystallization applications. Turbidity sensing can be performed by the Atlas Turbidity Probe and particle size analysis is possible through integration of a Focused Beam Reflectance Method (FBRM) sensor.
The Atlas SonoLab System is the latest addition to the highly successful range of Atlas automated synthesis products that includes systems for applications such as reaction calorimetry, pH monitoring and control, volumetric dosing, gravimetric dosing and many more. For more information, please visit www.syrris.com.
Syrris Limited
Established in 2001, Syrris Limited is one of the fastest growing science SMEs in the UK employing over 30 scientists and engineers at its facility in Royston (near Cambridge). Founders Mark Gilligan and Richard Gray come from a background of developing automation products for chemists at companies such as The Technology Partnership (TTP) and Mettler Toledo.
Syrris develops general productivity tools for chemists such as the Atlas automated chemistry systems. Atlas can be configured into a wide range of different systems including Lithium and Sodium for round bottom flasks (magnetically and overhead stirred respectively) and Potassium for jacketed vessels. Other Atlas systems, designed for specific applications, including calorimetry, volumetric dosing, gravimetric dosing, pH, etc, are also available.
Syrris also specialise in flow reactors for R&D chemists, including FRX: a low cost flow chemistry system and Africa (Automated Flow Reaction Incubation and Control Apparatus): a modular system for library synthesis, aqueous work-up and reaction optimization that will ultimately reduce the time taken to develop, synthesize, screen and review a chemical entity, thus vastly speeding up the drug discovery process.
In recognition of its technological achievements, Syrris has been awarded a prestigious UK DTI SMART Exceptional Grant. Syrris has also won a significant DTi MNT (Micro and Nano Technology) award which is being used to establish a new subsidiary called The Dolomite Centre Ltd. This new company is focused on design and fabrication of Microfluidic devices for a wide range of applications.
About Prosonix Ltd
Based in Oxford UK and Experts in Sound ScienceTM, Prosonix are acknowledged leaders in the commercialization of proprietary ultrasonic particle engineering technologies and added value ultrasonic process chemistry solutions for the pharmaceutical and related industries.
Prosonix’s team of chemists and engineers combine to give Prosonix a unique multidisciplinary approach and competitive advantage to solve customers’ complex particle engineering process problems, leveraging its proprietary intellectual property and patented ultrasonic processing equipment to deliver long term and sustainable value added solutions, enabling the cost effective manufacture of better medicines.
For more information, please visit: www.prosonix.co.uk
