Sigma Introduces New Whole Genome Amplification Kit

ST. LOUIS, Dec. 28 /PRNewswire-FirstCall/ -- Sigma, a division of Sigma- Aldrich Corporation , has launched a new whole genome amplification kit, GenomePlex(TM) Whole Genome Amplification (Product code WGA-1). In October 2004, Sigma entered into an exclusive licensing agreement with Rubicon Genomics to further develop and commercialize the GenomePlex WGA technology. The GenomePlex Whole Genome Amplification (WGA) kit utilizes a proprietary amplification method designed for robust and accurate amplification of limited source DNA.

In less than three hours, GenomePlex WGA successfully amplifies nanogram amounts of starting DNA, regardless of source, into microgram yields. The new GenomePlex WGA kit is sufficient for 50 reactions and recommended to be used with Sigma’s JumpStart(TM) Taq DNA Polymerase (Product code D9307). Additions to the whole genome amplification product line for 2005 are expected to include a kit sufficient for 100 reactions and a kit with JumpStart Taq DNA Polymerase included.

 Advantages of GenomePlex WGA include: -- Flexibility to study DNA from any source -- No detectable locus or allele bias -- Compatibility with a variety of microarray, capillary, and homogenous platforms for sequencing, genotyping, CGH, FISH, ChIP, forensics, and biosurveillance -- Increased sensitivity and accuracy for population studies, mutation discovery, and pharmacogenomics -- Robust amplification of problematic and highly degraded DNA from formalin-fixed, serum, buccal swab, archived, forensic and environmental samples -- Substantially faster than other WGA methods 

“The GenomePlex technology offers an efficient and economical approach to whole genome amplification,” commented Keith Jolliff, Global Marketing Manager of Molecular Biology at Sigma-Aldrich. “We are very excited about the GenomePlex technology and feel it is an excellent complement to our existing Nucleic Acid Amplification product line as well as our oligonucleotide offering through Sigma-Genosys. And, we are already developing the next generation of GenomePlex products, fully expecting to introduce two new kits with one sufficient for 100 reactions and the other with JumpStart Taq DNA Polymerase included in early 2005.”

Learn more about GenomePlex WGA kit at http://www.sigma-aldrich.com/wga1 .

About Sigma-Aldrich: Sigma-Aldrich is a leading Life Science and High Technology company. Our biochemical and organic chemical products and kits are used in scientific and genomic research, biotechnology, pharmaceutical development, the diagnosis of disease and as key components in pharmaceutical and other high technology manufacturing. We have customers in life science companies, university and government institutions, hospitals, and in industry. Over one million scientists and technologists use our products. Sigma-Aldrich operates in 34 countries and has over 6,000 employees providing excellent service worldwide. We are committed to the success of our Customers, Employees and Shareholders through leadership in Life Science, High Technology and Service.

This release contains forward-looking statements relating to future goals, strategic actions and initiatives and similar intentions and beliefs and other statements regarding the Company’s expectations, goals, beliefs, intentions and the like, which involve assumptions regarding Company operations and conditions in the markets the Company serves. The Company does not undertake any obligation to update these forward-looking statements.

Sigma-Aldrich Corporation

CONTACT: Tony Favello, +1-314-286-7879, or Joan Suda, +1-314-286-7626,both of Sigma-Aldrich Corporation

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