PUTNAM, CT USA – (January 21, 2016) – Foster Delivery Science, a leader in hot melt extrusions of drug delivery polymers, and the University of Texas at Austin School of Pharmacy, a leading pharmaceutical research institution, recently completed collaborative research in the field of drug formulation development. These studies confirm the application of ultrafiltration will reduce drug development time by rapid screening of amorphous solid dispersion formulations.
Amorphous solid dispersions are commonly used to improve the oral dose bioavailability of poorly water soluble drugs, such as the antifungal drug itraconazole. Improved bioavailability results from the free concentrations of active pharmaceutical ingredients that are solubilized in the polymer matrix. These free drug concentrations are required for absorption in the gastrointestinal tract.
Analytical techniques that are currently used to screen new formulations in early stage development for free drug concentration include diffusion and partition technologies, solution nuclear magnetic resonance spectroscopy, and ultraviolet spectrum analysis. However, these methods are complex and time consuming. Ultrafiltration requires less time to measure free drug concentrations of formulations, and can expedite drug development analysis of multiple formulations.
“Our recent studies confirmed the applicability of ultrafiltration to screen itraconazole formulations for free drug concentration,” said Tony Listro, Vice President of Foster Delivery Science. “This technique is quick and effective, and may allow formulators to accelerate the development of other solid dispersion formulations to improve bioavailability.” For more information about ultrafiltration please visit www.deliveryscience.com.
Amorphous solid dispersions are commonly used to improve the oral dose bioavailability of poorly water soluble drugs, such as the antifungal drug itraconazole. Improved bioavailability results from the free concentrations of active pharmaceutical ingredients that are solubilized in the polymer matrix. These free drug concentrations are required for absorption in the gastrointestinal tract.
Analytical techniques that are currently used to screen new formulations in early stage development for free drug concentration include diffusion and partition technologies, solution nuclear magnetic resonance spectroscopy, and ultraviolet spectrum analysis. However, these methods are complex and time consuming. Ultrafiltration requires less time to measure free drug concentrations of formulations, and can expedite drug development analysis of multiple formulations.
“Our recent studies confirmed the applicability of ultrafiltration to screen itraconazole formulations for free drug concentration,” said Tony Listro, Vice President of Foster Delivery Science. “This technique is quick and effective, and may allow formulators to accelerate the development of other solid dispersion formulations to improve bioavailability.” For more information about ultrafiltration please visit www.deliveryscience.com.
