Dr. Marc Siegel and Kevin Sills Join Oragenics, Inc.’ Board of Directors

ALACHUA, FL--(Marketwire - April 28, 2008) - Oragenics, Inc. (AMEX: ONI) announced today that Dr. Marc Siegel and Mr. Kevin Sills have been appointed to the Company’s Board of Directors. “Dr. Siegel is a leader in the discussion of healthcare, as a teacher of medicine, a practicing internist, and a familiar expert contributor to the national print and broadcast media on healthcare. Mr. Sills brings an impressive depth of pharmaceutical industry experience that includes novel drug formulations, clinical supplies design/production and product life cycle management. We anticipate that both new Directors will contribute significantly to the growth of Oragenics and we are pleased to welcome them to our Board,” stated Rick Welch, Chairman of Oragenics.

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