Nature communications: Breaking immune tolerance by targeting Foxp3+ regulatory T cells mitigates Alzheimer’s disease pathology
Researchers in Israel have manipulated the mouse immune system to target Alzheimer’s disease. The research was published in the journal Nature Communications on 18 August 2015.
Dr Laura Phipps from Alzheimer’s Research UK, said:
“The role of the immune system in Alzheimer’s disease is incredibly complex and researchers are working hard to unravel how best to target it to promote better brain health. This study in mice suggests that boosting immune cells that are entering the brain from the rest of the body could slow Alzheimer’s changes and benefit memory, but it is too soon to know the relevance for people living with dementia. We know that testing lots of different scientific approaches is crucial in the hunt for new treatments and it’s only through increased and sustained investment in dementia research that we will find the answers to our biggest medical challenge.”
Ends
For further information, or to speak with Dr Laura Phipps, please contact Emma O’Brien, Media Officer at Alzheimer’s Research UK on 0300 111 5 666 or email press@alzheimersresearchuk.org
Notes to editors:
• Ref: Breaking immune tolerance by targeting Foxp3+ regulatory T cells mitigates Alzheimer’s disease pathology by Kuti et al. is published on 18 August in Nature Communications.
• Alzheimer’s Research UK is the UK’s leading charity specialising in finding preventions, treatments and a cure for dementia.
• To help us defeat dementia, donate today by visiting www.alzheimersresearchuk.org or calling 0300 111 5555.
• We are currently supporting dementia research projects worth over £26 million in leading Universities across the UK.
• Our Defeat Dementia campaign, a pledge to raise £100 million in five years to grow the research field and accelerate progress towards new treatments and preventions, was announced by the Prime Minister at the G8 legacy event on 19 June 2014. For more information visit www.dementiablog.org/defeat-dementia
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