Therapeutic Solutions International Reports Unexpected Findings of Synergy between QuadraMune™ and Diabetes Drug Metformin in Animal Models of COVID-19 Lung Damage
OCEANSIDE, Calif., July 22, 2020 /PRNewswire/ -- Therapeutics Solutions International, Inc., (OTC Markets: TSOI), announced today filing of a patent showing potent synergy between QuadraMune™ and the antidiabetic drug metformin in treating COVID-19 associated lung damage models.
It was discovered that the ability of QuadraMune™ to protect the lungs from inflammation that resembles coronavirus-induced pathology is markedly amplified by concurrent administration of metformin.
At a mechanistic level, it was shown that metformin increased the ability of QuadraMune™ to:
a) increase the number of "healing macrophages" ("M2" macrophages);
"We are currently preparing to conduct a 500-person study evaluating protection from COVID-19 in individuals at high risk of infection, which is listed on the NIH website1," said Dr. James Veltmeyer, Chief Medical Officer of the Company. "In light of the current findings, we are extremely interested in evaluating outcomes in patients already taking metformin, which is one of the commonly used drugs in elderly populations."
Metformin has previously been shown to possess numerous therapeutic benefits in addition to its activities on diabetes. Beneficial effects of metformin include stimulation of immune responses2, suppression of cancer3, reduction of nicotine withdrawal side effects4, and inhibition inflammation5.
"It is naïve to believe that therapeutics that we develop will be used in isolation," said Timothy Dixon, President and CEO of the Company. "We are grateful for our scientific advisors who have guided us to perform 'out of the box' experiments in terms of combining QuadraMune™ with clinically relevant companion medications. We are continuing our journey to develop QuadraMune™ as a science-based nutraceutical, as well as to understand mechanistically its modes of action in order to continually work to improve potential for efficacy."
About Therapeutic Solutions International, Inc.
Therapeutic Solutions International, Inc.
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SOURCE Therapeutic Solutions International, Inc.
Company Codes: OTC-PINK:TSOI, OtherOTC:TSOI